Related Products of 4333-56-6, These common heterocyclic compound, 4333-56-6, name is Bromocyclopropane, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Cyclopropyl bromide (4.64 g, 38.4 mmol, 1.2eq) was dissolved in dry diethylether (50 mL) under argon, cooled to-78 C and treated with tert-BuLi (45 mL of a 1.7M solution in pentane, 76.5 mmol, 2.4eq). After 10 minutes, cooling was removed and the mixture stirred at room temperature for 1 hr. After recooling TO-40 OC, a solution of intermediate 4 (8.43 g, 32 mmol, 1EQ) in dry diethylether (40 mL) was added and stirring continued at- 40 C for 1.5 hrs. 5M HCI was added (50 mL) and the phases separated. The aqueous phase was washed with diethylether (discarded) and then basified with KOH pellets to pH > 10 in the presence of diethylether. The organic phase was washed with water and brine and then evaporated to DRYNESS IN VACUO to afford the title compound as a colourless oil (6.42 g, 86%) ; 1 H NMR (400MHZ, CDCI3) 0.13-0. 15 (1 H, m), 0.34-0. 37 (2H, m), 0.60 – 0. 70 (1 H, m), 0.83 (3H, d, J = 7Hz), 0.91 (3H, d, J = 7Hz), 0.98-1. 00 (1 H, m), 1.71- 1.77 (1 H, m), 2.44-2. 48 (1 H, m), 3.00 (1 H, d, J = 8Hz), 3.32 and 3.36 (1 H, dd, J = 5 and 11 Hz), 3.59 and 3.61 (1 H, dd, J = 5 and 11 Hz), 7.25-7. 42 (5H, m); m/z (APCI) : 234 [M+H] +.
Statistics shows that Bromocyclopropane is playing an increasingly important role. we look forward to future research findings about 4333-56-6.
Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2005/14575; (2005); A1;,
Bromide – Wikipedia,
bromide – Wiktionary