Reference of 626-88-0, A common heterocyclic compound, 626-88-0, name is 1-Bromo-4-methylpentane, molecular formula is C6H13Br, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Entry 7: 3,7-dimethyloctan-2-one (0.5 mmol, 78.1 mg). The remote product was 7-hydroxy-3,7-dimethyloctan-2-one (21), and the proximal product was 3-hydroxy-3,7-dimethyloctan-2-one. Purification by flash chromatography (35% EtOAc/hexanes), run 1 (46.0 mg, 0.267 mmol, 53%), run 2 (43.1 mg, 0.250 mmol, 50%). Average: 52%. Recovered starting material (rSM): 14.2 mg, 0.183 mmol, 18%. [Remote:Proximal]>99:1. Authentic proximal oxidation product was obtained by treating 1-bromo-4-methylpentane (1 equiv.) with Mg turnings (1 equiv.), followed by 2,3-butandione (1 equiv.) at -78 C. The reaction was quenched H2O, extracted with CH2Cl2 and purified by column chromatography (15% EtOAc/hexanes) to yield 3-hydroxy-3,7-dimethyloctan-2-one.
The synthetic route of 626-88-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; The Board of Trustees of the University of Illinois; US2011/15397; (2011); A1;,
Bromide – Wikipedia,
bromide – Wiktionary