Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4549-33-1, name is 1,9-Dibromononane, A new synthetic method of this compound is introduced below., 4549-33-1
General procedure: Finely ground KOH(4.48 g, 80 mmol) was added to a solution of pyrazole(2.72 g, 40 mmol) in DMSO (20 ml). The suspension wasthoroughly stirred for 30 min at 80, then treated bydropwise addition of 1,4-dibromobutane (4.32 g, 2.41 ml,20 mmol) in DMSO (10 ml) over 30 min, while cooling thereaction mixture with water. After finishing the addition ofdibrom derivative, stirring and heating at 80 wascontinued for additional 4 h, the reaction mixture wasthen poured into water (200 ml), extracted withchloroform (5¡Á10 ml), the extract was washed one timewith distilled water (10 ml) and dried over anhydrousCaCl2. Chloroform was removed by distillation undervacuum.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Zatonskaya, Lina V.; Schepetkin, Igor A.; Petrenko, Tatiana V.; Ogorodnikov, Vladimir D.; Khlebnikov, Andrei I.; Potapov, Andrei S.; Chemistry of Heterocyclic Compounds; vol. 52; 6; (2016); p. 388 – 401; Khim. Geterotsikl. Soedin.; vol. 52; 6; (2016); p. 388 – 401,14;,
Bromide – Wikipedia,
bromide – Wiktionary