These common heterocyclic compound, 1647-23-0, name is 1-Bromo-3,3-dimethylbutane, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 1647-23-0
The first step, weighed indole acetic acid (1.05g),Added to DMF (5 mL) and stirred to dissolve,Cooling to 0 ~ 5 C stirring;60% sodium hydride (0.72 g) was added,Stirring for 10min,3,3-dimethyl-1-bromobutane(1.5 g) was added,0 ~ 5 C reaction 0.5h,Slowly rose to room temperature reaction 2h;Add ethyl acetate (40mL), water (40mL); rapid mixing, 2min drop 6N hydrochloric acid solution 10mL,Stirring for 5 min; the phases were separated and the aqueous phase was extracted with ethyl acetate (20 mL). The phases were separated and the ethyl acetate phases were combined. Saturated brine(30 mL) for 5 min,The ethyl acetate phase was removed at 50 C under reduced pressure to give the crude product of the first step2- [1- (2-tert-butylethyl) -1H-indol-3-yl] acetic acid.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1647-23-0.
Reference:
Patent; Chinese Academy Of Medical Sciences Pharmaceutical Institute; Shi Jiangong; Guo Ying; Xu Chengbo; Chen Qing; Chen Minghua; Ba Mingyu; Zhu Chenggen; Tang Ke; Jiang Jiandong; Guo Jiamei; Guo Qinglan; Lin Sheng; Yang Yongchun; (44 pag.)CN107151223; (2017); A;,
Bromide – Wikipedia,
bromide – Wiktionary