55289-36-6, name is 3-Bromo-2-methylaniline, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 55289-36-6
To a solution of 10.0 g (53.7 mmol, 1.0 eq.) of 3-bromo-2-methylamine (LXXXVIIa) in 200 mL of acetonitrile at 0 C was added 42 mL of cone. HC1 followed by 42 mL of glacial acetic acid and a solution of 4.4 g (63.9 mmol, 1.1 eq.) of sodium nitrite in 12 mL of water. The mixture was purged with SO2 gas for 15 mm and a solution of 9.1 g (53.7 mmol, 1.0 eq.) ofcopper (II) chloride in 12 mL of water was added dropwise at 0 C. The mixture was allowed to warm to room temperature and stirred for 16 h. The mixture was concentrated in vacuo, diluted with 500 mL of water and extracted with 3 x 500 mL of ethyl acetate. The combined organic extracts were washed with 200 mL of sat. aqueous sodium bicarbonate solution, 200 mL of brine, dried (Na2SO4), filtered and the solvent was removed in vacuo. The residue waspurified by trituration with pentane to provide 8.0 g (29.7 mmol, 55%) of 3-bromo-2- methylbenzene-1-sulfonyl chloride (LXXXVIIIa). ?H NIVIR (400 MFIz, CDC13): 8.07 (d, 1H), 7.92 (d, 1H), 7.28 (t, 1H), 2.88 (s, 3H).
Statistics shows that 55289-36-6 is playing an increasingly important role. we look forward to future research findings about 3-Bromo-2-methylaniline.
Reference:
Patent; ARBUTUS BIOPHARMA CORPORATION; COLE, Andrew, G.; DORSEY, Bruce, D.; KAKARLA, Ramesh; KULTGEN, Steven; QUINTERO, Jorge; (353 pag.)WO2018/172852; (2018); A1;,
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