Adding a certain compound to certain chemical reactions, such as: 38573-88-5, name is 1-Bromo-2,3-difluorobenzene, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 38573-88-5, 38573-88-5
Under a nitrogen atmosphere, 2,2,6,6-tetramethylpiperidine (48.5 mL) and THF (250 mL) were put in a reaction vessel, and the resulting mixture was cooled to 0¡ãC. Then, n-butyllithium (1.60 M; n-hexane solution; 178 mL) was slowly added thereto, and the resulting mixture was stirred for 1 hour. Next, the resulting mixture was cooled to -70¡ãC, and then a THF (500 mL) solution of compound (T-1) (50.0 g) was slowly added thereto, and stirred for 1 hour, and then N,N-dimethylformamide (DMF) (40.1 mL) was slowly added thereto, and stirred for 12 hours while the mixture was returned to room temperature. The resulting reaction mixture was poured into a saturated aqueous solution of ammonium chloride, and the resulting aqueous layer was subjected to extraction with ethyl acetate. Then, organic layers combined were washed with brine, and dried over anhydrous magnesium sulfate. The resulting solution was concentrated under reduced pressure, and the residue was purified by silica gel chromatography (hexane : ethyl acetate = 5 : 1 in a volume ratio). Then, the resulting product was further purified by recrystallization from a mixed solvent of hexane and ethyl acetate (1 : 1 in a volume ratio) to give compound (T-2) (46.9 g; 82percent).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-2,3-difluorobenzene, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; JNC Corporation; JNC Petrochemical Corporation; TANAKA, Hiroyuki; ENDOU, Hiroshi; EP2957554; (2015); A1;,
Bromide – Wikipedia,
bromide – Wiktionary