615-54-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 615-54-3, name is 1,2,4-Tribromobenzene, A new synthetic method of this compound is introduced below.
Under an argon stream, 1.50 g (6.02 mmol) of 4- (2-quinolyl) phenylboronic acid,542 mg (1.72 mmol) of 1,2,4-tribromobenzene,159 mg (0.138 mmol) of tetrakis (triphenylphosphine) palladium,And 7.74 mL (7.74 mmol) of 1 M potassium carbonate aqueous solution were dissolved in 60 mL of dioxane,And the mixture was heated and stirred at 100 C.After cooling to room temperature, 500 mL of pure water was added and the mixture was separated and extracted with chloroform.After distilling off the solvent under reduced pressure, the obtained crude product was recrystallized twice using toluene as a solvent,Objective4,4 ” – di (2-quinolyl) -4 ‘- [4- (2-quinolyl) phenyl] -1,1’: 2 ‘, 1 “Of a white solid (yield 680 mg, yield 57.5%).
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Reference:
Patent; TOSOH CORPORATION; FUJITA, KANA; ARAI, NOBUMICHI; NOMURA, KEISUKE; IIDA, TAKASHI; TANAKA, TSUYOSHI; (76 pag.)JP6264877; (2018); B2;,
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