Some common heterocyclic compound, 55289-36-6, name is 3-Bromo-2-methylaniline, molecular formula is C7H8BrN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 55289-36-6
To a solution of compound 298a (8g, 43mmol) in dichloromethane (80ml) at 0 C was added compound 298b (16ml, 113.5mmol). The reaction solution was stirred at 0 C for 30 minutes, and then solid potassium nitrate (5.43g, 53.7 mmol), the ice bath was removed, and the reaction solution was stirred at room temperature for 4 hours. LCMS monitored the reaction of the raw materials. The reaction solution was concentrated and dried under vacuum. The residue was added with water and extracted twice with dichloromethane (2 * 200 ml). The organic phases were combined, dried over anhydrous sodium sulfate, and filtered with suction.It was dried and the crude product was passed through the column to obtain a yellow solid compound (Example 298c, 4.0972g, yield 28.57%).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 55289-36-6, its application will become more common.
Reference:
Patent; Jiaxing Tekeluo Biological Technology Co., Ltd.; Xing Li; Li Guanqun; Wang Xiaolei; Cai Yuting; Jiang Xiang; Pan Xiang; Zhu Wenhao; Wang Yang; Wang Zengquan; (83 pag.)CN110627775; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary