52997-43-0, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 52997-43-0 as follows.
Under nitrogen protection, nitrogen is protected. The intermediate product 1, 2 – bis (4 -hydroxyphenyl) ethane -1, 2 – diketone (2g, 8.26 mmol), potassium carbonate (2.4g, 0.2 mmol), tetrabutylammonium bromide (1.33g, 4.13 mmol) were dissolved in N 70 ml) solutions, followed by 60 C stirring 1h, followed by 7 – (bromomethyl) pentadecane (4.04g, 13.2 mmol), 120 C and refluxing 24h out unitunit_ type. After completion of the reaction, the reaction was completed. The reaction solution was cooled to room temperature, and saturated 200 ml brine and dichloromethane were added thereto to extract, and the organic phase, dried over anhydrous magnesium sulfate, concentrated, and then subjected to column chromatography separation and purification. The eluate containing the objective compound was collected by column 300 – 400 silica gel as a 1:3 stationary phase, eluting, with a dichloromethane/petroleum ether volume ratio timetime mixture and dried, yielding a yellow powdery intermediate product 1, 2 – bis (4 – (hexadecyloxy) phenyl) ethane -1, was obtained. 2 – Diketone 3.05g, yield=unitz 45.4%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 52997-43-0, and friends who are interested can also refer to it.
Reference:
Patent; Zhejiang University of Technology; Lv Xiaojing; Bi Qian; Ouyang Mi; Qian Liang; Xu Xinjia; Zha Lixia; (13 pag.)CN110066287; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary