These common heterocyclic compound, 1559-88-2, name is 3-Bromo-1,2,4,5-tetrafluorobenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 1559-88-2
General procedure: An oven-dried Schlenk tube equipped with a stir bar was charged with Pd(OAc)2 (4.5 mg, 0.02 mmol, 10 mol%), aryliodine(III) diacetate (0.24 mmol) and Ag2CO3 (82.7 mg, 0.3 mmol). The tube was fitted with a rubber septum, and then it was evacuated and refilled with nitrogen three times. Under nitrogen, polyfluoroarene (0.2 mmol), DMSO(0.1 mL) and DMF (2 mL) were added successively. The rubber septum was replaced with a Teflon screw cap under nitrogen flow. With stirring, the reaction mixtures were heated at 110 C for the indicated amount of time (unless otherwise specified), and then cooled down to roomtemperature. The resultant mixture was filtered through a short plug of silica gel and then concentrated in vacuo. The residue was then purified by flash chromatography on silica gel to provide the corresponding product.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1559-88-2.
Reference:
Article; Fu, Zhengjiang; Xiong, Qiheng; Zhang, Wenbiao; Li, Zhaojie; Cai, Hu; Tetrahedron Letters; vol. 56; 1; (2015); p. 123 – 126;,
Bromide – Wikipedia,
bromide – Wiktionary