3814-30-0, Name is (Bromomethyl)cyclopentane, 3814-30-0, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows.
Weigh 165.7mg (1.02mmol) of bromomethylcyclopentane and dissolve it in DMF, add it dropwise to the reaction flask and stir for 5min, and dropwise add 73mg (1.12mmol) of sodium azide solution ( DMF solution), argon protection, 100 C reflux stirring reaction for 12h, complete reaction was detected by TLC, add pure water, extract with EtOA, wash with water, dry with MgSO4, filter with suction and concentrate the dried product, then dissolve its EtOAc and add dropwise to the reaction flask During stirring for 5 min, 110 mg (1.02 mmol) of p-benzoquinone (EtOAc dissolved) was added dropwise, protected by argon, and the reaction was stirred at 70 C under reflux for 24 h. The reaction was completed by TLC, the reaction was terminated, and the crude product was obtained by concentration and drying. The crude product was separated by Combiflash (RediSep Column: Silica 20g, column retention volume was 78ml), and the elution gradient was EtOAc: PE = 20:80. The fractions were analyzed by TLC, combined and dried to obtain 22.5mg of compound ZY011901 and 22.5mg of compound ZY011903
Statistics shows that (Bromomethyl)cyclopentane is playing an increasingly important role. we look forward to future research findings about 3814-30-0.
Reference:
Patent; Guangzhou University Of Traditional Chinese Medicine (Guangzhou Traditional Chinese Medicine Institute); Liu Jiawei; Yu Qiang; Zheng Yangqing; Zhang Qing; Ma Hongyan; Zeng Xinling; Zhou Qing; Wen Liangxi; Liu Jingli; Li Min; Xia Fan; (49 pag.)CN110872299; (2020); A;,
Bromide – Wikipedia,
bromide – Wiktionary