Adding some certain compound to certain chemical reactions, such as: 327-52-6, name is 1-Bromo-2,4,5-trifluorobenzene, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 327-52-6. 327-52-6
To magnesium spalls in a reaction flask, under an atmosphere of nitrogen, was added 50 ml tetrahydrofuran and 0.02 g iodine as an initiator. A solution of 9 g 1-bromo-2,4,5-trifluorobenzene in 150 ml tetrahydrofuran was added dropwise into the reaction system. The reaction was stirred at 25 C. for 3 h to obtain a solution of 0.21 mol/L (2,4,5-trifluorophenyl)-magnesium bromide.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1-Bromo-2,4,5-trifluorobenzene.
Reference:
Patent; ZHEJIANG JIUZHOU PHARMACEAUTICAL CO., LTD.; Gao, Hongjun; Li, Min; US2013/12735; (2013); A1;,
Bromide – Wikipedia,
bromide – Wiktionary