Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 82842-52-2, name is 3-Bromo-2,4,6-trimethylaniline, This compound has unique chemical properties. The synthetic route is as follows., 82842-52-2
(B) 2,2′-[[2-[(3-bromo-2,4,6-trimethylphenyl)amino]-2-oxoethyl]]imino]bisacetic acid A suspension of 9.56 g of nitrilotriacetic acid in pyridine (dried over molecular sieves) is prepared with the exclusion of moisture (CaSO4 drying tube) and heated to 50 C. Acetic anhydride (5.11 g) is added dropwise. The reaction mixture clears and is heated to 100 C. After maintaining the temperature for 40 minutes, the reaction mixture is cooled to 55 C. and a solution of 10.7 g 3-bromo-2,4,6-trimethylaniline in 25 ml of dry pyridine is added slowly. The reaction is heated to 100 C. and after 1.5 hours at this temperature, the solution is cooled in an ice-bath. The reaction mixture is rotary evaporated to a semisolid which is dissolved in 125 ml of 10% sodium hydroxide w/v. The basic layer is then extracted with two 100 ml portions of methylene chloride. Distilled water (100 ml) is added to the basic layer which is then brought to pH 3 with concentrated hydrochloric acid to give a precipitate. After refrigeration for about 16 hours, the crude product is filtered, washed with cold distilled water and dried under vacuum at 40 C. The crude product is dissolved in 100 ml of 60% aqueous ethanol, treated with 3.0 g of Darco and filtered hot through a Hyflo-bed to give a solution. Crystals precipitate and are filtered, washed with three 25 ml portions of 50% aqueous ethanol and dried under vacuum at 40 C. The reaction yields 9.1 g of the title compound, melting point 198-200 C., dec.
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Reference:
Patent; E. R. Squibb & Sons, Inc.; US4418208; (1983); A;,
Bromide – Wikipedia,
bromide – Wiktionary