955959-84-9, These common heterocyclic compound, 955959-84-9, name is 4-(4-Bromophenyl)dibenzo[b,d]furan, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
In a 250 ml three-necked flask, 0.012 mol of the raw material 1-1, 0.010 mol of the raw material II-1, and 150 ml of toluene were added and stirred under a nitrogen atmosphere.Then add 5¡Á10-5 mol Pd2(dba)3, 5¡Á10-5 mol P(t-Bu)3, 0.03 mol sodium tert-butoxide, heated to 105 C, refluxed for 24 hours, sampling the plate, showing no bromine remaining, the reaction is complete; naturally cooled to room temperature, filtered, and the filtrate is rotary evaporated to no fraction, and passed through a neutral silica gel column to obtain the desired product intermediate B-1; HPLC purity 99.93%, yield 77.3%;
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 955959-84-9.
Reference:
Patent; Jiangsu March Optoelectric Technology Co., Ltd.; Tang Dandan; Li Chong; Zhang Zhaochao; Ye Zhonghua; (71 pag.)CN109761967; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary