In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 452-92-6 as follows. 452-92-6
To a solution of 5-bromo-2,4-difluoro aniline (1.0 g, 4.81 mmol) in acetone (25.0 ml.) was added drop wise benzoyl isothiocyanate (0.71 mL, 5.29 mmol). The resulting reaction mixture was allowed to stir at room temperature for 30 min. After the completion of the reaction (TLC monitoring), the solvent was evaporated and the residue was washed with hexane and ether to get the title compound (1.70 g, quantitative yield) as a white solid. 1H-NMR (400 MHz, CDCI3): delta 7.02-7.06 (m, 1 H), 7.56 (t, J= 8.0 Hz, 2H), 7.68 (t, J= 7.60 Hz, 1 H), 7.91 (d, J= 7.60 Hz, 2H), 8.67 (t, J= 7.60 Hz, 1 H), 9.15 (br s, 1 H) and 12.65 (br s, 1 H).
According to the analysis of related databases, 452-92-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; PROLYSIS LTD; WO2009/74812; (2009); A1;,
Bromide – Wikipedia,
bromide – Wiktionary