A new synthetic route of 7-Bromopyrrolo[2,1-f][1,2,4]triazin-4-amine

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 937046-98-5, and friends who are interested can also refer to it.

937046-98-5, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 937046-98-5 as follows.

Intermediate Rl-A: 7-Bromo-5-iodopyrrolo[2,l-f][l,2,4]triazin-4-amine (Rl-A) To a solution of 7-bromopyrrolo[2,l-f][l,2,4]triazin-4-amine (4 g, 18.78 mmol) in anhydrous DMF (200 mL) was added NIS (4.65 g, 20.65 mmol) and the mixture was stirred in the dar

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 937046-98-5, and friends who are interested can also refer to it.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; BHIDE, Rajeev S.; RUAN, Zheming; CHERNEY, Robert J.; CORNELIUS, Lyndon A.M.; DHAR, T.G. Murali; GONG, Hua; MARCOUX, David; POSS, M