Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 626-40-4, name is 3,5-Dibromoaniline, A new synthetic method of this compound is introduced below., 626-40-4
2.51 g (10.0 mmol) of 3,5-dibromophenylamine, 4.48 g (22.0 mmol) of iodobenzene, 0.58 g (0.5 mmol) of Pd (PPh ) (Tetrakis (triphenylphosphine) palladium (0)) and 6.21 g (45.0 mmol) of K CO were mixed with THF (tetrahydrofuran) / H 0(2/1) After dissolving in 40 mL of the solution, the mixture was stirred at 80 C. for 5 hours. The reaction solution was cooled to room temperature, and thenextracted three times with 40 mL of water and 40 mL of diethyl ether. The organic layer thus obtained was dried over magnesium sulfate and the residue obtainedby evaporation of the solvent was separated and purified by silica gel column chromatography to obtain Intermediate I-4 (2.11 g, 86% yield). The resulting compound was confirmed by LC-MS.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Samsung Display Co., Ltd.; Kim Yeong-guk; Hwang Seok-hwan; Jeong Hye-jin; Park Jun-ha; Lee Eun-yeong; Im Jin-o; Han Sang-hyeon; Jeong Eun-jae; Kim Su-yeon; Lee Jong-hyeok; (64 pag.)KR102052070; (2019); B1;,
Bromide – Wikipedia,
bromide – Wiktionary