7745-91-7, Adding a certain compound to certain chemical reactions, such as: 7745-91-7, name is 3-Bromo-4-methylaniline, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 7745-91-7.
Step 1 : 3-bromo-4-methylaniline (1.0 equiv), hexane-2,5-dione (1.1 equiv.) and -TsOH (0.05 equiv.) were combined in toluene (0.4 M) and the mixtore heated in Dean- Stark at 150 C. After 35 min, the reaction mixture was cooled to room temperature. The reaction mixture was let to age at room temperature for 60 h and then concentrated in vacuo. The residue was purified by flash chromatography (0-10% EtO Ac/heptane to afford the desired product 1 -(3 -bromo-4-methylphenyl)-2,5 -dimethyl- lH-pyrrole in 92% yield. LCMS (m/?) (M+H) = 265.8, Rt = 1.13 min.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Bromo-4-methylaniline, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; NOVARTIS AG; AVERSA, Robert John; BURGER, Matthew T.; DILLON, Michael Patrick; DINEEN JR., Thomas A.; LOU, Yan; NISHIGUCHI, Gisele A; RAMURTHY, Savithri; RICO, Alice C.; RAUNIYAR, Vivek; SENDZIK, Martin; SUBRAMANIAN, Sharadha; SETTI, Lina Quattrocchio; TAFT, Benjamin R.; TANNER, Huw Rowland; WAN, Lifeng; (307 pag.)WO2016/38582; (2016); A1;,
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