These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 40161-54-4, its application will become more common.
Some common heterocyclic compound, 40161-54-4, name is 1-Bromo-2-fluoro-4-(trifluoromethyl)benzene, molecular formula is C7H3BrF4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 40161-54-4
INTERMEDIATE 7 MC181 Y4-[2-Bromo-5-(trifluoromethyl)phenoxy]cvclohexanolTo a solution of 4-bromo-3-fluorobenzotrifluoride (2 g, 8.23 mmol) and a mixture of cis and trans cyclohexane-l,4-diol (3.82 g, 32.9 mmol) in DMF (41.2 ml) was added NaH 5 (0.658 g, 16.46 mmol) at 0 C. The reaction mixture was warmed to room temperature then heated at 80 0C for 2 h. The mixture was poured onto IN HCl (100 mL) and extracted with EtOAc (3×25 mL). The combined organic fractions were washed with water (50 mL) then dried over Na2SO4. Purification by Combiflash chromatography (SiO2-40 g, gradient elution of 10- 50% EtOAc/hexanes over 25 min) afforded the title product as a 7:3 mixture of isomers. 10 Major isomer: 1H NMR (500 MHz, acetone-d6): delta 7.82 (dd, IH), 7.43 (d, IH), 7.23 (d, IH), 4.76-4.70 (m, IH), 3.84-3.76 (m, IH), 3.67 (d, IH), 2.18-2.12 (m, IH), 2.06-1.95 (m, IH), 1.82-1.71 (m, 2H), 1.69-1.60 (m, 2H), 1.55-1.47 (m, 2H). MS: m/z 339, 341 (MH+).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 40161-54-4, its application will become more common.
Reference:
Patent; MERCK FROSST CANADA LTD.; WO2008/128335; (2008); A1;,
Bromide – Wikipedia,
bromide – Wiktionary