The chemical industry reduces the impact on the environment during synthesis 142808-15-9, name is 4-Bromo-2-fluorobenzotrifluoride, I believe this compound will play a more active role in future production and life. 142808-15-9
At -78 C., 181.07 ml of a 2.5M (452.7 mmol) solution of n-butyllithium were added dropwise to a solution of 63.9 g (452.7 mmol) of 2,2,6,6-tetramethylpiperidine in 833 ml of dry THF. The mixture was stirred at this temperature for 30 min. 100.0 g (411.5 mmol) of 4-bromo-2-fluoro-1-(trifluoromethyl)benzene were then added dropwise at -78 C. The mixture was stirred at this temperature for 2 h. 33.1 g (452.7 mmol) of DMF were then added dropwise at -78 C. The reaction mixture was then stirred for 2 h. For work-up, 300 ml of water were added to the contents. The mixture was extracted three times with in each case 200 ml of dichloromethane. The combined organic phases were washed with 300 ml of 1M hydrochloric acid and then with 300 ml of a saturated aqueous sodium chloride solution. The organic phase was dried and the filtrate was freed of the solvent. 96.2 g of the desired product were obtained.
The chemical industry reduces the impact on the environment during synthesis 142808-15-9. I believe this compound will play a more active role in future production and life.
Reference:
Patent; BAYER CROPSCIENCE AKTIENGESELLSCHAFT; AHRENS, Hartmut; TIEBES, Joerg; WALDRAFF, Christian; DIETRICH, Hansjoerg; SCHMUTZLER, Dirk; GATZWEILER, Elmar; ROSINGER, Christopher; (33 pag.)US2017/107183; (2017); A1;,
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