The chemical industry reduces the impact on the environment during synthesis 38573-88-5, name is 1-Bromo-2,3-difluorobenzene, I believe this compound will play a more active role in future production and life. 38573-88-5
Preparation 8; TERT-BUTYL S-^1S-DIFLUOROPHENYL)-S-HYDROXYAZETIDINE-I – CARBOXYLATE; To a solution of 3-bromo-1 ,2-difluorobenzene (2.3 g, 11.8 mmol) in dry diethylether (20 ml) at -78¡ãC, under nitrogen was added n-butyllithium (2.5 M in hexane, 4.7 ml, 11.8 mmol) dropwise. The mixture was stirred for 1 h after which a solution of 1-Boc-3-azetidinone (2.0 g, 11.7 mmol) in dry diethyl ether (20 mL) was added dropwise. The resulting mixture was stirred at -78¡ãC for 15 min and then brought to ambient temperature and stirred for 2 h. Aqueous ammonium chloride (50 mL, 50percent) and diethylether was added, the organic phase was collected and the aqueous phase was extracted with ethyl acetate (2×50 ml). The combined organic phase was dried (Na2SO4), filtered and evaporated to dryness. The crude product was purified by flash column chromatography on silica gel (ethylacetate/isooctane 1 :4 to 1 : 1 ) to give the title compound (1.9 g). MS m/z (rel. intensity, 70 eV) 285 (M+, 1 ), 156 (55), 141 (69), 127 (bp), 57 (88).
The chemical industry reduces the impact on the environment during synthesis 38573-88-5. I believe this compound will play a more active role in future production and life.
Reference:
Patent; NSAB, FILIAL AF NEUROSEARCH SWEDEN AB, SVERIGE; SONESSON, Clas; SWANSON, Lars; PETTERSSON, Fredrik; WO2010/58017; (2010); A1;,
Bromide – Wikipedia,
bromide – Wiktionary