586-61-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 586-61-8 as follows.
5-cyano-2-fluorobenzeneboronic acid pinacol ester (1.98 g, 8.0 mmol) and 4-bromoisopropylbenzene (2.39 g, 12 mmol) were dissolved in 20 ml of dioxane, and Pd(PPh3)4 was added. (924 mg, 0.8 mmol) and CsCO3 (5.2 g, 16.0 mmol) were reacted at 90 C overnight under nitrogen. The reaction liquid was filtered through diatomaceous earth.The filtrate was spin-dried and then subjected to petroleum ether column chromatography to yield 1.35 g of colorless oily liquid, yield: 70.6%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 586-61-8, and friends who are interested can also refer to it.
Reference:
Patent; China Pharmaceutical University; You Qidong; Xu Xiaoli; Jiang Fen; Guo Anping; Xu Jiachen; (26 pag.)CN108147978; (2018); A;,
Bromide – Wikipedia,
bromide – Wiktionary