Some common heterocyclic compound, 615-36-1, name is 2-Bromoaniline, molecular formula is C6H6BrN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 615-36-1
General procedure: Compound 2b-l were synthesized according to the reported method:1A mixture of aniline (10 mmol), iodoalkane (22 mmol) and K2CO3(22mmol) in DMF (80 mL) was refluxed at 75 C. After completion of thereaction monitored by TLC, the mixture was poured into aqueous NaHCO3solution and extracted with ethyl acetate. The organic layer was washed with brine,dried over sodium sulfate and concentrated in vacuo. Purification by columnchromatography on silica gel produced N,N-dimethylanilines 2b-l.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 615-36-1, its application will become more common.
Reference:
Article; Shen, Hang; Zhang, Xiaohui; Liu, Qing; Pan, Jing; Hu, Wen; Xiong, Yan; Zhu, Xiangming; Tetrahedron Letters; vol. 56; 41; (2015); p. 5628 – 5631;,
Bromide – Wikipedia,
bromide – Wiktionary