67567-26-4, name is 4-Bromo-2,6-difluoroaniline, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 67567-26-4
4-Bromo-2,6-difluoro-phenylamine (200 g, 0.961 mol) and N-isopropyl acetamide (107 g, 1.057 mol) in toluene (1000 mL) were stirring at 10-15 C. Phosphoryl chloride (177 g, 1.154 mol) and triethylamine (117 g, 1.156 moles) were slowly added. The reaction mixture was heated to reflux for 2-3 hours. The reaction mass was cooled to 10-15 C and water was slowly added into the reaction mixture which was stirred at 30-35 C for 15-20 minutes. The pH of the reaction mass was adjusted to 7.5-8.0 with a sodium hydroxide solution, stirred for 30 minutes at 30-35 C, and the layers were separated. The organic layer was washed with water and the layers were againseparated. Potassium hydroxide (161.5 g, 2.88 mol) and dimethylsulfoxide 400 mL at 30-35 Cwere charged to the organic layer. The reaction mixture was heated to reflux and water wasadded azeotropically for 2-4 hours at reflux temperature. The reaction mass was cooled to 25-30C and water was slowly added into the reaction mixture. The reaction mixture was stirred at 30-35 C for 15-20 minutes and the layers were separated. The organic layer was washed with anaqueous sodium chloride solution. The organic layer was concentrated under vacuum. Toluene (160 mL) and hexanes (1000 mL) were charged to the residue and the resulting mixture was stirred for 2-3 hours at room temperature. The mixture was filtered and the collected solid was washed with hexanes and dried at 50-55 C to yield 215 g (82.3%) of 6-bromo-4-fluoro-1- isopropyl-2-methyl-1H-benzoimidazole with a purity of 99.70%.
Statistics shows that 67567-26-4 is playing an increasingly important role. we look forward to future research findings about 4-Bromo-2,6-difluoroaniline.
Reference:
Patent; MYLAN LABORATORIES LIMITED; JETTI, Ramakoteswara Rao; INDUKURI, Anjaneyaraju; BOMMAREDDY, Aggi Ramireddy; SRINIVASARAO, Attanti Veera Venkata; JEBARAJ, Rathinapandian; CHANDUPATLA, Shivakumar; BATHARAJU, Ramesh; KUNAMNENI, Sunil; (74 pag.)WO2019/102492; (2019); A1;,
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