61326-44-1, Name is 1,1,2,2-Tetrakis(4-bromophenyl)ethene, 61326-44-1, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows.
General procedure: The synthesis of intermediate tetra-brominated TPE has been reported in previous literatureS1. The solid reactant 2 (100 mg, 0.15 mmol) and solid reactant 3 (0.9 mmol), catalyst palladium acetate (1.73 mg, 0.0077 mmol) and triphenylphosphine (4.04 mg, 0.0154 mmol) was added into the cube which was pumped three times, then anhydrous and anaerobic DMF (5 ml) and bubbled triethylamine(1 ml) was injected. After quickly switching the stopper, the reaction system would flux for two days. When completed, the reaction was cooled to room temperature, then poured into a large amount of water and extracted three times with dichloromethane, and finally washed with saturated saline multiple times to obtain the organic phase. After the organic phase was dried over anhydrous sodium sulfate, the dichloromethane was swirled off by rotary evaporation. TPE-Py was purified by silica gel column chromatography (petroleum ether : ethyl acetate = 1:5) to obtain the solid yellow powder, otherwise TPE-Ph was eluted by petroleum ether/dichloromethane (1:2) to acquire the orange powder.
Statistics shows that 1,1,2,2-Tetrakis(4-bromophenyl)ethene is playing an increasingly important role. we look forward to future research findings about 61326-44-1.
Reference:
Article; Ma, Xiaoxie; Hu, Linli; Han, Xie; Yin, Jun; Chinese Chemical Letters; vol. 29; 10; (2018); p. 1489 – 1492;,
Bromide – Wikipedia,
bromide – Wiktionary