28342-75-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 28342-75-8, name is 1,5-Dibromo-2,4-difluorobenzene, A new synthetic method of this compound is introduced below.
1. Add 1 mmol of 1,5-dibromo-2,4-difluorobenzene, 2.2 mmol of nitrogen-containing heterocyclic compound and 2.27 mmol of potassium carbonate to 5 mL of dimethyl sulfoxide.Then reacted for 6 h under an argon atmosphere at a temperature of 130 C.Obtaining a mixed solution I containing a reactant;The mixed solution I containing the reactant was extracted with a mixture of water and dichloromethane, and then the organic layer obtained after the extraction was dried using anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure using a rotary evaporator to give a crude reaction. Product I; using solvent I as a rinse, the crude reaction product I is purified by column chromatography to obtain 1,5-dicarbazole-2,4-dibromobenzene;The nitrogen-containing heterocyclic compound described in the first step is oxazole;The solvent I described in the first step is a mixed solution of petroleum ether and dichloromethane, the volume ratio of petroleum ether to dichloromethane in the solvent I is 5:1;The volume ratio of water to dichloromethane in the mixture of water and dichloromethane described in the first step is 1:5;
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Heilongjiang University; Xu Hui; Duan Chunbo; Han Chunmiao; Liang Qianqian; (46 pag.)CN107325811; (2019); B;,
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