156682-52-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 156682-52-9, name is 1,4-Dibromo-2,3-difluorobenzene, A new synthetic method of this compound is introduced below.
1,4-Dibromo-2,3-difluorobenzene (15 g, 55.2 mmol), (2-methoxyphenyl) boronic acid in a mixture of water (140 ml) and dioxane (140 ml)(8.80 g, 57.9 mmol), sodium carbonate(11.69 g, 110 mmol) and tetrakis(Triphenylphosphine) palladium (0)(3.19 g, 2.76 mmol) was dissolved.The reaction mixture was degassed and heated in an 80 C. oil bath for 20 hours. The reaction mixture is cooled to room temperature, mixed with brine,Extracted with EtOAc. Washing the extract with water and brine;Dry and evaporate to obtain a solid / liquid mixture,Adsorbed on a silica gel plug,Subjected to silica gel column chromatography,Elution with heptane as a colorless oil4-Bromo-2,3-difluoro-2′-methoxy-1,1′-biphenyl was obtained.(12.5 g, 75% yield).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Universal Display Corporation; Zhiqiang, Ji; Jui Yi, Tsai; Alexey, Borisovich Dyatkin; Chun, Lin; (197 pag.)JP2019/127489; (2019); A;,
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bromide – Wiktionary