Adding a certain compound to certain chemical reactions, such as: 61613-22-7, name is 2-Bromo-N-phenylaniline, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 61613-22-7, 61613-22-7
After dissolving 10 g of 2-bromo-N-phenylphenylamine in 100 ml of tetrahydrofuran,The reaction temperature was lowered to -78 C, 20 ml of 2.5 M butyllithium was slowly added dropwise and stirred for 1 h.15.2 g of bis (4-chlorophenyl) methanone was dissolved in 150 ml of tetrahydrofuranAfter slowly adding dropwise, the temperature was increased to room temperature and stirred for 12 h. After the reaction is completed, distilled water and water will be usedMethylene chloride and dried under anhydrous magnesium sulfate and then filtered under reduced pressure, without further purificationPure and directly dissolved in 150 ml of acetic acid, 10 ml of sulfuric acid was added dropwise and the mixture was stirred under reflux. After the reaction is over, useDistilled water and methylene chloride and the resulting solid was subjected to column purification to give compound 9-1 (10 g, yield62%).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Bromo-N-phenylaniline, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Changchun Hai Purunsi Technology Co., Ltd.; Liu Xiqing; Cai Hui; (24 pag.)CN107400085; (2017); A;,
Bromide – Wikipedia,
bromide – Wiktionary