586-61-8, Name is 1-Bromo-4-isopropylbenzene, 586-61-8, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows.
A mixture of 10 g(50 mmol) 1-bromo-4-isopropylbenzene, 7.4 g(55 mmol) of 4-isopropylaniline, 0.25 g(1 mmol) of palladium(II)acetate, 0.75 g(2.0 mmol) of 2-(dicyclohexylphosphino)biphenyl, 9.6 g(100 mmol) of sodium tert-butoxide and 100 ml of o-xylene was refluxed under nitrogen overnight. After finishing the reaction, the solution was filtered at 100 C., to receive the filtrate, and the filtrate was added to 1 L MeOH, while stirring and the precipitated product was filtered off with suction. To give 4.7 g(yield 37%) of yellow product which was recrystallized from hexane.
Statistics shows that 1-Bromo-4-isopropylbenzene is playing an increasingly important role. we look forward to future research findings about 586-61-8.
Reference:
Patent; LUMINESCENCE TECHNOLOGY CORPORATION; Yen, Feng-Wen; (56 pag.)US9537103; (2017); B1;,
Bromide – Wikipedia,
bromide – Wiktionary