3814-30-0, name is (Bromomethyl)cyclopentane, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 3814-30-0
EXAMPLE 2 Preparation of 1-(cyclopentylmethyl)imidazole A solution of sodium ethoxide was made by dissolving sodium (2.3 g, 0.1 mole) in absolute ethanol (100 ml). Imidazole (6.8 g, 0.1 mole) was then added. The mixture was heated under reflux and cyclopentylmethylbromide (16.3 g, 0.1 mole) was added dropwise. The reaction mixture was allowed to reflux for a further 16 hours after addition. The mixture was then left to cool. The solid material was then filtered off and the filtrate evaporated down under vacuum. The residue was taken up in 2 N HCl (150 ml) and washed with ether (50 ml). The solution was basified with excess 10 N NaOH and the product extracted with chloroform (3*50 ml). Combined extracts were dried over anhydrous MgSO4 and chloroform removed under vacuum to give yellowish oil. The crude product was purified on a silica gel column eluted with EtOAc/MeOH (9:1). The product fractions were combined and evaporated down under vacuum to leave 1.9 g of slightly yellowish oil. This was distilled under vacuum. B.pt. 68-69 C./0.125 mmHg. Yield 0.95 g.
Statistics shows that 3814-30-0 is playing an increasingly important role. we look forward to future research findings about (Bromomethyl)cyclopentane.
Reference:
Patent; Burroughs Wellcome Co.; US4284641; (1981); A;,
Bromide – Wikipedia,
bromide – Wiktionary