A common compound: 327-52-6, name is 1-Bromo-2,4,5-trifluorobenzene, belongs to bromides-buliding-blocks compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below. 327-52-6
EXAMPLE H 3-Bromo-2,5,6-trifluorobenzaldehyde To a solution of 1-bromo-2,4,5-trifluoro benzene (25 g, 0.12 mol) in THF (200 mL) at -78 C. was added LDA (80 mL, 1.5 M) dropwise. The mixture was stirred at -78 C. for 1 hour, then N-formylpiperidine (16 g, 0.144 mol) was added in one portion and stirring continued for 2 hours. An additional 15 g of N-formylpiperidine was then added every 0.5 hour in 5 g portions. The reaction was quenched with 3N HCl (pH 3) at -78 C. The reaction was warmed to 0 C. and partitioned between H2 O and ether. The ether layer was dried and concentrated and the residue was distilled to provide 13 g (45%) of the desired aldehyde; bp 63-65 C. (0.2 mm).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 327-52-6, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Warner-Lambert Company; US5047538; (1991); A;,
Bromide – Wikipedia,
bromide – Wiktionary