327-52-6, A common heterocyclic compound, 327-52-6, name is 1-Bromo-2,4,5-trifluorobenzene, molecular formula is C6H2BrF3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Dissolve 2,4,5-trifluorobromobenzene (10.5 g 49.8 mmol) in tetrahydrofuran (25 mL) with methyl tert-butyl ether(25 mL), cooled to -30 C, isopropyl magnesium chloride (4.8 g 46.5 mmol) was slowly added dropwise to the solution, stirred at -30 C for 10 min, and added with cuprous chloride (1.6 g 16.6 mmol). After stirring at -30C for 15 min, the compound of formula 3 (6.1 g 33.2 mmol) was dissolved in methyl tert-butyl ether (20 mL) and slowly added dropwise to the reaction system. The temperature rose from -30C to -3C within 3 h. At 10C, it was warmed to -5C over a further 3 h and reacted overnight at 0C. Saturated ammonium chloride (25 mL) was added to the reaction system, extracted with ethyl acetate (20 mL*1), washed with saturated brine, dried over anhydrous sodium sulfate, concentrated and stirred with petroleum ether (50 mL) to obtain 15.6 g. Product 4, yield 90%.
The synthetic route of 327-52-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Heding (Nanjing) Pharmaceutical Co., Ltd.; Li Wensen; (18 pag.)CN105017081; (2017); B;,
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bromide – Wiktionary