The chemical industry reduces the impact on the environment during synthesis 28342-75-8, name is 1,5-Dibromo-2,4-difluorobenzene, I believe this compound will play a more active role in future production and life. 28342-75-8
l,5-Dibromo-2,4-difluorobenzene (1, 1.36 g, 5.00 mmol) was dissolved in dry diethyl ether ( 15 mL) and cooled down to -78C. 2.35 M n-Butyllithium in hexane (2.20 mL, 5.25 mmol) was added drop-wise with stirring . After 15 minutes, dry N,N- dimethylformamide (0.77 mL, 10.0 mmol) was added and the resulting mixture was stirred at for 15 minutes and then allowed to warm to ambient temperature. After one hour, the reaction mixture was quenched with 1.0 M aqueous solution of hydrochloric acid ( 15 mL) . Layers were separated and the organic layer was washed with brine ( 15 mL), dried over anhydrous magnesium sulfate and evaporated . The residue was purified by flash column chromatography (Silicagel 60, 0.063-0.200 mm ; eluent: cyclohexane/ ethyl acetate 20 : 1) 5-bromo-2,4-difluorobenzaldehyde (2) as colorless oil which solidified on storage in freezer. Yield : 780 mg (70%) . JH NM R spectrum (300 MHz, CDCI3, deltaEta) : 10.26 (s, 1 H) ; 8.14 (dd, J =9.6 and 8.0 Hz, 1 H) ; 7.05 (d, J = 8.0 Hz, 1 H) .
The chemical industry reduces the impact on the environment during synthesis 28342-75-8. I believe this compound will play a more active role in future production and life.
Reference:
Patent; NOVO NORDISK A/S; KRUSE, Thomas; HANSEN, Mikael, Kofoed; MUeNZEL, Martin, Werner, Borchsenius; TH?GERSEN, Henning; SAUERBERG, Per; RASMUSSEN, Jakob, Ewald; BEHRENS, Carsten; H?EG-JENSEN, Thomas; BAL?ANEK, Vojtech; DROBNAKOVA, Zuzana; DRO?, Ladislav; HAVRANEK, Miroslav; KOTEK, Vladislav; ?TENGL, Milan; ?NAJDR, Ivan; VANOVA, Hana; (202 pag.)WO2019/92125; (2019); A1;,
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