Share a compound : 1-Bromo-2,4,5-trifluorobenzene

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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 327-52-6, name is 1-Bromo-2,4,5-trifluorobenzene, This compound has unique chemical properties. The synthetic route is as follows., 327-52-6

Step 1: (2-Bromo-4,5-difluorophenyl)(methyl)sulfaneIn a 40 mL vial, a solution of 1-bromo-2,4,5-trifluorobenzene (2.00 g, 9.48 mmol)in DMSO (15 mL) was treated with NaSMe (3.32 g, 47.4 mmol), and the resultingsuspension stirred at room temperature for 4 h. The reaction mixture was diluted with DCM, and the organics were washed with water and brine. The volatiles were concentrated to give (2-bromo-4,5-difluorophenyl)(methyl)sulfane (2.20 g, 98 %), which was used without further purification in next reaction. ?H NMR (400MHz, CDC13) oe7.23 (dd, J=8.7, 5.7 Hz, 1H), 6.98 (dd, J=8.5, 6.4 Hz, 1H), 2.46 (s, 3H). HPLC: RT =2.756 mm; (Chromolith ODS S5 4.6 x 50 mm (4 mm grad) 0-100% B. Flow Rate = 4ml/min. Inj. Vol. = 10 uL. Wavelength = 220. Oven Temp. = 40 C. Solvent A: 10%MeOH – 90% H20 -0.1 % TFA. Solvent B: 90% MeOH – 10 % H20 – 0.1 % TFA).

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Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; NORRIS, Derek J.; DELUCCA, George V.; GAVAI, Ashvinikumar V.; QUESNELLE, Claude A.; GILL, Patrice; O’MALLEY, Daniel; VACCARO, Wayne; LEE, Francis Y.; DEBENEDETTO, Mikkel V.; DEGNAN, Andrew P.; FANG, Haiquan; HILL, Matthew D.; HUANG, Hong; SCHMITZ, William D.; STARRETT, JR, John E.; HAN, Wen-Ching; TOKARSKI, John S.; MANDAL, Sunil Kumar; WO2015/100282; (2015); A1;,
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