A common heterocyclic compound, 344-03-6, name is 1,4-Dibromotetrafluorobenzene, molecular formula is C6Br2F4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 344-03-6.
A mixture of 5,5′-bis(tri-n-butylstannyl)-2,2′-dithiophene (4.62 g, 4.87 mmol), 1,4-dibromoperfluorobenzene (6.00 g, 19.48 mmol) and tetrakis(triphenylphosphine)palladium(0) (0.12 g, 0.10 mmol) in dry DMF (20 mL) was deareated twice with nitrogen. The reaction mixture was then heated at 85¡ã C. for 20 h during which time a precipitate formed. After cooling, the orange solid was collected and washed several times with hexane and ether to afford the crude product which was purified by gradient sublimation (2.14 g, 3.42 mmol, 70.2percent yield). M.p. 231¡ã C. 1H NMR (CDCl3) delta 7.60 (2H, d, 2J=4.1), 7.34 (2H, d); 19F NMR (CDCl3) delta -133.58 (4F), -138.56 (4F). Anal. Calcd for C20H4Br2F8S2: C, 38.72; H, 0.65; F, 24.51. Found: C, 38.75; H, 0.78; F, 24.29.
The synthetic route of 1,4-Dibromotetrafluorobenzene has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Marks, Tobin J.; Facchetti, Antonio; US2008/293937; (2008); A1;,
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