553-94-6, Name is 2,5-Dimethylbromobenzene, 553-94-6, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows.
Add 15 mL of solvent dichloromethane to a 100 mL round bottom flask and weigh 3.0 g (16.21 mmol)2,5-Dimethylbromobenzene was added to a round bottom flask containing dichloromethane to make them mutually soluble, put into a stir bar, and stirred under ice water bath; 10 mL of dichloromethane was added to a 100 mL beaker, and 3.240 g was quickly weighed. (24.32 mmol) anhydrous aluminum chloride powder was added to a beaker containing dichloromethane, 2.36 g (27.56 mmol) of acetyl chloride was weighed into a beaker, and stirred with a glass rod to completely dissolve anhydrous aluminum trichloride. After dissolving, it was transferred to a constant pressure funnel, and then slowly and continuously added dropwise to the above 2,5-dimethylbromobenzene solution, and the reaction was stirred under an ice water bath condition; after the dropwise addition, the ice water bath was stirred for 1 hour, and the ice water bath was removed. The reaction was stirred at room temperature for 15 h; after the reaction was over, the burgundy solution obtained by the reaction was slowly added to a beaker containing 300 mL of cold water, and continuously stirred with a glass rod until the solution turned from burgundy to yellowish, and after cooling, Dichloromethane extraction (extraction 2 times, once with 100 mL), the lower layer of methylene chloride was retained, poured into a 500 mL beaker, dried over anhydrous sodium sulfate for 5 h, dried and filtered, and then evaporated. The solvent is removed, and the crude product is added. 100mL round bottom flask was added n-hexaneRecrystallization. The crude product was crystallized to give 2.76 g of white crystals, yield 75%.
Statistics shows that 2,5-Dimethylbromobenzene is playing an increasingly important role. we look forward to future research findings about 553-94-6.
Reference:
Patent; Heilongjiang University; Li Hongfeng; Wang Cheng; Sun Zhiyao; Sun Longjiang; Zheng Rongrong; Ma Dongge; Guo Dechao; Cui Guofeng; Yan Pengfei; (24 pag.)CN109096084; (2018); A;,
Bromide – Wikipedia,
bromide – Wiktionary