10016-52-1, A common compound: 10016-52-1, name is 2,8-Dibromodibenzo[b,d]furan, belongs to bromides-buliding-blocks compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below.
In a nitrogen atmosphere, a flask containing 2,8-dibromodibenzo[b,d]furan (2.5 g), (10-phenylanthracen-9-yl) boronic acid (5.7 g), Pd-132 (0.27 g), tetrabutylammonium bromide (0.25 g), potassium carbonate (3.2 g), water (10 ml), and toluene (100 ml) was stirred at a reflux temperature for two hours. The reaction liquid was cooled to room temperature and subjected to liquid separation. The obtained organic layer was washed with water. This solution was decolorized using silica gel and concentrated under reduced pressure. The precipitated solid was washed with heptane to obtain compound (2A-201) (2.5 g). The structure of the compound thus obtained was identified by an NMR analysis. 1H-NMR (400 MHz, CDCl3):delta=8.06?8.05 (m,2H), 7.93?7.90 (m,2H), 7.77?7.70 (m,8H), 7.65?7.55 (m,8H), 7.55?7.47 (m,4H), 7.36?7.31 (m,8H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,8-Dibromodibenzo[b,d]furan, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Kwansei Gakuin Educational Foundation; JNC Corporation; HATAKEYAMA, Takuji; TAJIMA, Akio; BABA, Daisuke; FUJITA, Yukihiro; YAMAGA, Yuko; IMAI, Hiroyuki; (139 pag.)US2019/312207; (2019); A1;,
Bromide – Wikipedia,
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