Extended knowledge of 2-(4-Bromophenyl)ethanamine

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 73918-56-6 as follows. 73918-56-6

A solution of 4-bromophenylethyl amine (4.7 g, 23.5 mmol) and Et3N (6.5 mL, 47.0 mmol) in 100 mL of CH2Cl2 is cooled to -30 0C. Benzyl chloroformate (4 ml, 28.2 mmol) is added drop-wise. The reaction mixture is allowed to warm up to 23 0C slowly and stirred for 5 h. The reaction mixture is poured into crushed ice- water and extracted with CH2Cl2 (100 mL x 3). The organic layer is washed with water, brine, and dried over Na2SO4, and concentrated in vacuo. The crude product is purified by passing through a silica gel pad and eluting with 5% MeOH in CH2Cl2 and then 1 :2 EtOAc-hexanes to give the desired intermediate 1.1 (7.5 g, 97%) as a white solid.

According to the analysis of related databases, 73918-56-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG; WO2009/52078; (2009); A1;,
Bromide – Wikipedia,
bromide – Wiktionary