174508-31-7, Name is 5,7-Dibromo-2,3-dihydrothieno[3,4-b][1,4]dioxine, 174508-31-7, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows.
4 Benzenamine, N, N-diphenyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl) (1) (0.419 g, 1.1 mmol), 2,5-Dibromo-3,4-ethylenedioxythiophene(0.2999 g,1 mmol), were dissolved in 30 ml DMF. a solution of K2CO3 (2 M, 10 ml) and two drops of aliquat 336 solution were added and degassed under argon for 30 min then Tetrakis(triphenyl-phosphine)palladium(0) (0.034 g, 0.03 mmol) added to the solution. The reaction mixture was stirred at 90 C for 24 h and quenched by adding water. The resulting mixture was extracted with methylene chloride.The combined organic layers dried over Na2SO4, and filtered. After removing the solvent, a yellow solid was obtained, which was purifiedby silica gel chromatography by using chloroform as eluent to give the title compound as a yellow solid. Yield (43%). FT-IR (cm-1): 1587(C = C aromatic), 1272 (C-N aromatic amine), 726 (C-Br)1H NMR(500 MHz, DMSO-d6, delta): 7.53-7.47 (m, 2H), 7.31-7.20 (m, 6H), 7.11-7.04 (m, 4H), 7.00 (m, 2H), 4.29 (s, 4H). MS: m/z (C24H18BrNO2S)found=463.02 (calcd. 464.37 For [M+]) with an error of DeltaM = 0.7963 ppm.
Statistics shows that 5,7-Dibromo-2,3-dihydrothieno[3,4-b][1,4]dioxine is playing an increasingly important role. we look forward to future research findings about 174508-31-7.
Reference:
Article; Abdellah, Islam M.; Koraiem, Ahmed I.; El-Shafei, Ahmed; Dyes and Pigments; vol. 164; (2019); p. 244 – 256;,
Bromide – Wikipedia,
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