38573-88-5, These common heterocyclic compound, 38573-88-5, name is 1-Bromo-2,3-difluorobenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Under nitrogen atmosphere, diisopropylamine (25.2 g) was dissolved in THF (130 mL) and cooled to -70 ¡ã C. or lower. To the solution, a 1.6 M butyl lithium / hexane solution (130 mL) was added dropwise at a rate such that the internal temperature did not reach -65 ¡ã C., and then the mixture was stirred at -70 ¡ã C. or less for 30 minutes. Subsequently, a solution prepared by dissolving 2,3-difluorobromobenzene (40 g) in THF (150 mL) was added dropwise to the stirring reaction solution at a rate such that the internal temperature did not exceed -65 ¡ã C., For 1 hour. Subsequently, a solution of DMF (22.7 g) dissolved in THF (220 mL) was added dropwise at a rate such that the internal temperature did not become -65 ¡ã C. or higher, followed by stirring at -70 ¡ã C. or lower for 1 hour, then slowly And the mixture was heated to room temperature. 10percent hydrochloric acid and toluene were added to the reaction solution, the organic layer was separated, and the organic layer was washed with saturated brine. Sodium sulfate was added to the organic layer after washing and dried, and then the solvent was distilled off under reduced pressure to obtain a crude product (44.9 g) of 4-bromo-2,3-difluorobenzaldehyde.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 38573-88-5.
Reference:
Patent; DIC CORPORATION; TOJO, KENTA; KUSUMOTO, TETSUO; TAKATSU, HARUYOSHI; (13 pag.)JP6019595; (2016); B2;,
Bromide – Wikipedia,
bromide – Wiktionary