1422-54-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1422-54-4, name is 2-Bromo-6-fluorotoluene belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Example 42 Preparation of (4-bromo-2-fluoro-3-methylphenyl)dimethyl(phenyl)silane To a 100 mL flask charged with THF (30 mL) was added diisopropylamine (1.285 g, 12.70 mmol). The reaction flask was cooled to -78 C. in a dry ice acetone bath and n-butyllithium (0.746 g, 11.64 mmol) was added. After 40 min of stirring at -78 C., 1-bromo-3-fluoro-2-methylbenzene (2 g, 10.58 mmol) in THF (10 mL) was added dropwise. Once an additional 40 min at -78 C. had passed, chlorodimethyl(phenyl)silane (5.42 g, 31.7 mmol) was added in one portion, the dry ice/acetone bath was removed and the reaction mixture was allowed to warm to room temperature. The reaction mixture was neutralized with a 5% HCl solution and diluted with water (200 mL). The aqueous solution was washed with EtOAc (200 mL*2). The combined organic layers were dried over Na2SO4. Following filtration, the organics were concentrated and the resulting residue was purified by flash chromatography with a gradient eluent system of hexanes and EtOAc to yield a clear oil as a mixture of products that contained (4-bromo-2-fluoro-3-methylphenyl)dimethyl(phenyl)silane which was used without further purification (850 mg): ESIMS m/z 324 ([M+H]+1).
The synthetic route of 1422-54-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Dow AgroSciences LLC; ECKELBARGER, Joseph D.; EPP, Jeffrey B.; FISCHER, Lindsey G.; GIAMPIETRO, Natalie C.; KISTER, Jeremy; PETKUS, Jeffrey; ROTH, Joshua; SATCHIVI, Norbert M.; SCHMITZER, Paul R.; SIDDALL, Thomas L.; YERKES, Carla N.; US2014/274703; (2014); A1;,
Bromide – Wikipedia,
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