1435-51-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1435-51-4, name is 1,3-Dibromo-5-fluorobenzene, This compound has unique chemical properties. The synthetic route is as follows.
General procedure: To 2,6-dimethoxyphenylboronic acid (4.50 mmol, 819 mg) in a mixture of toluene (45.0 mL), 2 M aqueous Na2CO3 (18.0 mL) and EtOH (9 mL) were successively added under Argon 1-fluoro-3-iodo-benzene (3.00 mmol, 666 mg) and Pd(PPh3)4 (0.15 mmol, 173 mg). This well-stirred mixture was heated at reflux for 18 h and then diluted at 25 C with water (100 mL) and toluene (50 mL). The aqueous layer was separated and washed with CH2Cl2 (2 ¡Á 100 mL). All the organics layers were combined, dried over Na2SO4 and concentrated under reduced pressure. Purification of the residue by column chromatography (cyclohexane/CH2Cl2 75:25) followed by crystallization from MeOH afforded biaryl 4a as a colorless solid (380 mg, 55%).
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Reference:
Article; Diemer, Vincent; Garcia, Juan Sanz; Leroux, Frederic R.; Colobert, Francoise; Journal of Fluorine Chemistry; vol. 134; (2012); p. 146 – 155;,
Bromide – Wikipedia,
bromide – Wiktionary