50548-45-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 50548-45-3 as follows.
A 250 ml reactor was charged with 2.3 g (24.7 mmol) of aniline, 7.4 g (30 mmol) of 1-bromodibenzofuran, 0.4 g (0.3 mmol) of palladium acetate,4.2 g (43 mmol) of sodium tertiary butoxide, 0.1 g (0.3 mmol) of tri-tert-butylphosphine,100 ml of toluene was added and the mixture was refluxed and stirred for 13 hours.After completion of the reaction, the reaction mixture was filtered, and the filtrate was concentrated and separated by column chromatography to obtain 4.0 g of Intermediate 8-a. (Yield: 63percent)
According to the analysis of related databases, 50548-45-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; SFC CO LTD; SFC Ltd.; CHOI YEONG TAE; Choi Yeong-tae; LEE SE JIN; Lee Se-jin; PARK SEOK BAE; Park Seok-bae; YU TAE JUNG; Ryu Tae-jeong; YANG BYUNG SUN; Yang Byeong-seon; LEE DA JUNG; Lee Da-jeong; (87 pag.)KR2018/31385; (2018); A;,
Bromide – Wikipedia,
bromide – Wiktionary