Some common heterocyclic compound, 54879-20-8, name is 2-Bromo-3-methylaniline, molecular formula is C7H8BrN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 54879-20-8
Add a solution of 4- (trifluoromethyl) benzoyl chloride (3.55 mL, 23 mmol) in methylene chloride (50 mL) dropwise over 5 min to a solution of 2-bromo-3-methylphenylamine (Step 1, 4.45 g, 23 mmol) in pyridine (60 mL) at 0LC under nitrogen, warm the mixture to room temperature and stir for 13 h. Dilute the mixture equally with 1 N HCl (500 mL) and extract with methylene chloride (3 x 250 mL). Dry the combined organic extracts over MGS04 and remove the solvents under reduced pressure to afford N- (2-BROMO-3-METHYLPHENYL)-4- trifluoromethylbenzamide (Step 2) as an off-white solid (8.3 g, 968) : 1H NMR (CDC13) 5 2.50 (s, 3H), 7.00 (d, 1H), 7.30 (t, 1H), 7.80 (d, 2H), 8.00 (d, 2H), 8.30 (d, 1H), 8.50 (br s, 1H) ; APCI MS M/Z 358 [C15HLLF3BRNO-H]-.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 54879-20-8, its application will become more common.
Reference:
Patent; ELI LILLY AND COMPANY; WO2004/63155; (2004); A1;,
Bromide – Wikipedia,
bromide – Wiktionary