A common heterocyclic compound, 53592-10-2, name is 2,4-Dibromo-1,1′-biphenyl, molecular formula is C12H8Br2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 53592-10-2.
General procedure: 10.0 g (81.4 mmol) of pyridine-3-boronic acid (CAS No.: 1692-25-7), 29.2 g (81.4 mmol) of 2-bromo-3′-iodobiphenyl (CAS No.: 1776936-09-4) and 93 ml of an aqueous 2 M Na2CO3 solution (186 mmol) are suspended in 75 ml of ethanol and 120 ml of toluene. To this suspension is added 0.94 g (0.82 mmol) of tetrakis(triphenyl)phosphinepalladium(0). The reaction mixture is heated under reflux for 16 h. After cooling, the organic phase is removed, filtered through silica gel, washed three times with 150 ml of water and then concentrated to dryness. After the crude product has been filtered through silica gel with heptane/ethyl acetate, 19 g (79%) of 3-(2′-bromobiphenyl-3-yl)pyridine are obtained.
The synthetic route of 2,4-Dibromo-1,1′-biphenyl has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Merck Patent GmbH; WIRGES, Christian; MUJICA-FERNAUD, Teresa; MONTENEGRO, Elvira; VOGES, Frank; MAIER-FLAIG, Florian; EBERLE, Thomas; (167 pag.)US2020/55822; (2020); A1;,
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